Survivin and p53 expression in benign and malignant lesions of breast

Breast cancer is the most common malignancy in women, accounting for 14 % of all cancers India; it accounts < 1% cases men. leading cause death worldwide. The study aims to assess expression p53 and Survivin Fibroadenoma Invasive carcinoma no special type its prognostic importance. A total number 75 are included study, out which 34 reported by two histopathologists as invasive NST (ductal) 41 Fibroadenoma. All females. Immunohistochemistry performed both groups with positive negative controls. Cytoplasmic or nuclear IHC considered be positive. Whereas, positivity p53. semi quantitative scoring system consisting intensity cells. found high IDC, 79% 85% respectively. correlation significant (p value = 0.002, Spearman Rho correlation). However, seen one third (37.5%) expectedly low, 12% cases. Over IDC patients compared benign correlated expression. Though likely contribute apoptosis resistance, confer resistance chemotherapy radiotherapy IDC. Henceforth, over along breast defining overall poor prognosis low survival rates.